![]() ![]() No one should take more than 300 mcg per day of chromium without the supervision of a doctor. 15 Whether these problems were caused by chromium picolinate or, if so, whether other forms of chromium might have the same effects at these high amounts remains unclear. These include itching and flushing of the skin and irritation of the stomach. Research found that it decreased cravings for carbohydrates, fast foods, high-fat foods, and sweets over time 10. 14 A case of a muscle disease known as rhabdomyolysis appeared in a body builder who took 1200 mcg over 48 hours. Other, generally minor side effects of chromium supplementation have been reported. One study looked at the effects of chromium picolinate supplementation on overweight adult women who reported food cravings. 1,000 mcg of chromium picolinate, taken in at least two doses throughout the day. Selected patients have developed a rash with chromium picolinate. Expert analysis on potential benefits, dosage, side effects, and more. 13 A case of anemia, liver dysfunction, and other problems appeared after four to five months of 1,200–2,400 mcg per day. It may increase glucose uptake, glycogen synthase activity and GLUT4 expression. A case of kidney failure appeared after taking 600 mcg per day for six weeks. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Upset stomach or throwing up. Three single, unrelated cases of toxicity have been reported from use of chromium picolinate. side effects, comorbidities, the risk of hypoglycemia, cost, and patient. 12 However, no published evidence supports this assertion. Influence of silymarin and chromium picolinate on the pharmacotherapy of rats. Another source claimed that there have been reports of mild heart rhythm abnormalities with excessive chromium ingestion. For example, a report published in The Annals of Pharmacotherapy described the case of a 33-year-old woman who developed kidney failure, liver damage, and anemia after taking 1200-2400 mcg of chromium picolinate (approximately 6-12 times the RDA. 11 However, chromium supplementation was not proven to be the cause of these problems. Rare clinical cases of side effects have been reported after taking chromium picolinate supplements. One report of severe illness (including liver and kidney damage) occurring in a person who was taking 1,000 mcg of chromium per day has been reported. 9 In theory, these changes could increase the risk of cancer, but so far, chromium intake has not been linked to increased incidence of cancer in humans. 7, 8 Chromium picolinate can be altered by antioxidants or hydrogen peroxide in the body to a form that could itself create free radical damage. One study suggested that chromium in very high concentrations in a test tube could cause chromosomal mutations in ovarian cells of hamsters. ![]() While there are a few reports of people developing medical problems while taking chromium, a cause-effect relationship was not proven. In supplemental amounts (typically 50–300 mcg per day), chromium has not been found to cause toxicity in humans. ![]()
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